The OASL Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to OASL, and Oasl1. This antibody recognizes Human, Mouse, and Rat antigen. The OASL Antibody has been validated for the following applications: ELISA, Immunocytochemistry, Immunofluorescence, and Western Blot.
Description
OASL (2'-5'-oligoadenylate synthetase-like), also known as p59OASL or TRIP14 (thyroid receptor-interacting protein 14), is a 514 amino acid protein that exists as two alternatively spliced isoforms, designated p56 and p30, and contains two ubiquitin-like domains (1). It is widely expressed in a variety of tissues and interacts with the ligand binding domain of the thyroid receptor (TR) and is able to bind double-stranded RNA and DNA, possibly playing a role in RNA degradation and the overall inhibition of protein synthesis (2-3). Methyl CpG-binding protein 1 (MBD1), which functions as a transcriptional repressor, was identified as a strong p59 OASL interactor (4)